Linnan Li

linnanli@shutcm.edu.cn

I develop new mass spectrometry, chromatography, and sample-pretreatment technologies for the precise analysis of complex natural-medicine systems.

Ph.D. in analytical chemistry from Peking University · B.S. in chemistry from Sichuan University.

✉ Email Google Scholar ORCID

Research Interests

My work spans the full chain of natural-medicine analysis — from discovering and characterizing active constituents, to decoding their molecular mechanisms, to safeguarding product quality and safety.

Analytical Technology Innovation

Mass Spectrometry · Chromatography · Sample Pretreatment

Developing new mass spectrometry, chromatography, and sample-pretreatment methods for the precise analysis of complex natural-medicine systems.

Active Ingredient Discovery

Natural Products

Discovery and structural characterization of bioactive constituents in traditional Chinese medicines.

Targeting Analysis & Metabolomics

Metabolomics · Molecular Targeting

Endogenous molecular targeting analysis and metabolomics to unravel mechanisms of action.

Quality Control & Safety

Green Chemistry · Quality Control

Green-chemistry strategies plus the quality control and safety evaluation of natural products.

Affiliations & Contact

Affiliations

State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine

MOE Key Laboratory of Standardization of Chinese Medicines

SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines

Shanghai Key Laboratory of Compound Chinese Medicines

Contact

Room 908, International Center for Standardization of Chinese Medicine
1200 Cailun Road, Zhangjiang Hi-Tech Park, Pudong District, Shanghai 201203, China
Tel: +86-21-51322417
Email: linnanli@shutcm.edu.cn

selected publications

J. Pharm. Anal.

Unraveling pyrrolizidine alkaloid-induced liver damage with an integrative spatial lipidomics framework

Yilin Chen, Jie Xu, Thomas Ka-Yam Lam, Yanqiao Xie, Jianing Wang, Aizhen Xiong, Zhengtao Wang, Zongwei Cai, Linnan Li^*, and Li Yang^*

Journal of Pharmaceutical Analysis, 2026

DOI Bib

@article{chen2025jpa,
  title = {Unraveling pyrrolizidine alkaloid-induced liver damage with an integrative spatial lipidomics framework},
  author = {Chen, Yilin and Xu, Jie and Lam, Thomas Ka-Yam and Xie, Yanqiao and Wang, Jianing and Xiong, Aizhen and Wang, Zhengtao and Cai, Zongwei and Li, Linnan and Yang, Li},
  journal = {Journal of Pharmaceutical Analysis},
  volume = {16},
  number = {1},
  pages = {101340},
  year = {2026},
  doi = {10.1016/j.jpha.2025.101340},
}

J. Adv. Res.

Rare ginsenosides: a unique perspective of ginseng research

Wenxiang Fan, Linhong Fan, Ziying Wang, Yuqi Mei, Longchan Liu, Linnan Li, Li Yang^*, and Zhengtao Wang^*

Journal of Advanced Research, 2024

DOI Bib

@article{fan2024jar,
  title = {Rare ginsenosides: a unique perspective of ginseng research},
  author = {Fan, Wenxiang and Fan, Linhong and Wang, Ziying and Mei, Yuqi and Liu, Longchan and Li, Linnan and Yang, Li and Wang, Zhengtao},
  journal = {Journal of Advanced Research},
  volume = {66},
  pages = {303--328},
  year = {2024},
  doi = {10.1016/j.jare.2024.01.003},
}

Anal. Chem.

Ion mobility mass spectrometry for the separation and characterization of small molecules

Longchan Liu, Ziying Wang, Qian Zhang, Yuqi Mei, Linnan Li^*, Huwei Liu, Zhengtao Wang, and Li Yang^*

Analytical Chemistry, 2023

DOI Bib

@article{liu2023analchem,
  title = {Ion mobility mass spectrometry for the separation and characterization of small molecules},
  author = {Liu, Longchan and Wang, Ziying and Zhang, Qian and Mei, Yuqi and Li, Linnan and Liu, Huwei and Wang, Zhengtao and Yang, Li},
  journal = {Analytical Chemistry},
  volume = {95},
  number = {1},
  pages = {134--151},
  year = {2023},
  doi = {10.1021/acs.analchem.2c02866},
}

Mass Spectrom. Rev.

Advances in mass spectrometry imaging for toxicological analysis and safety evaluation of pharmaceuticals

Yilin Chen#, Yanqiao Xie#, Linnan Li^*, Zhengtao Wang, and Li Yang^*

Mass Spectrometry Reviews, 2023

DOI Bib

@article{chen2023msr,
  title = {Advances in mass spectrometry imaging for toxicological analysis and safety evaluation of pharmaceuticals},
  author = {Chen#, Yilin and Xie#, Yanqiao and Li, Linnan and Wang, Zhengtao and Yang, Li},
  journal = {Mass Spectrometry Reviews},
  volume = {42},
  number = {5},
  pages = {2207--2233},
  year = {2023},
  doi = {10.1002/mas.21807},
}

Coord. Chem. Rev.

Recent advances in applications of metal–organic frameworks for sample preparation in pharmaceutical analysis

Linnan Li, Yilin Chen, Li Yang, Zhengtao Wang^*, and Huwei Liu^*

Coordination Chemistry Reviews, 2020

DOI Bib

@article{li2020ccr,
  title = {Recent advances in applications of metal–organic frameworks for sample preparation in pharmaceutical analysis},
  author = {Li, Linnan and Chen, Yilin and Yang, Li and Wang, Zhengtao and Liu, Huwei},
  journal = {Coordination Chemistry Reviews},
  volume = {411},
  pages = {213235},
  year = {2020},
  doi = {10.1016/j.ccr.2020.213235},
}