publications

2026

  1. Phytomedicine
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    Novel insights into anti-inflammatory activity-related metabolic markers and biosynthetic regulatory mechanisms between principal and lateral roots of Aconitum carmichaelii Debx. via integrated metabolomics and transcriptomics
    Wenhan Pei, Fan He, Ying Xie, Zhengtao Wang, Linnan Li, Li Yang*, and Hua Zhou*
    Phytomedicine, 2026
  2. Talanta
    zhang2026talanta.jpg
    Comprehensive volatile profiling and origin authentication of sandalwood via a dual-mode HS-SPME-arrow-GC-MS strategy
    Yingmin Zhang, Yanqiao Xie, Haizhen Zhang, Qiong Lai, Wenxiang Fan, Hongyuan Hao, Chen Shen, Ge Yin, Taohong Huang, Zhengtao Wang*, Linnan Li*, and Li Yang*
    Talanta, 2026
  3. Food Res. Int.
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    Beyond saponins: An integrated mass spectrometry strategy for profiling, spatial mapping, and rapid authentication of non-saponin constituents in Panax species
    Wenxiang Fan, Ziwei Li, Longchan Liu, Linnan Li, Rufeng Wang, Zhengtao Wang, Qiong Lai*, Lin Zheng*, and Li Yang*
    Food Research International, 2026
  4. Anal. Chim. Acta
    xie2026aca.jpg
    Unraveling the thermal release dynamics and pyrolysis signatures of agarwood by gas-liquid microextraction and gas chromatography-mass spectrometry
    Yanqiao Xie#, Jinhua Zhao#, Shengqi Huang, Chen Shen, Yi Zhou, Ge Yin, Hechen Wang, Linnan Li, Donghao Li*, Zhengtao Wang*, and Li Yang*
    Analytica Chimica Acta, 2026
  5. J. Chromatogr. A
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    A green and efficient boronate affinity solid-phase extraction strategy for ginsenosides enrichment based on dendritic mesoporous silica
    Weiman Zhao, Longchan Liu, Wenxiang Fan, Ziwei Li, Haizhen Zhang, Linnan Li*, Zhengtao Wang*, and Li Yang*
    Journal of Chromatography A, 2026
  6. Chem. Commun.
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    Enhanced-sensitivity profiling of natural products from TLC plates using a facile graphite-based LA-DART-MS platform
    Xingyu Wang, Jianxing Lv, Yilin Chen, Liying You, Linnan Li*, Zhengtao Wang, and Li Yang*
    Chemical Communications, 2026
  7. TrAC Trends Anal. Chem.
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    Miniature mass spectrometry in drug and food analysis: bridging laboratory and field applications
    Yanqiao Xie#, Liying You#, Xingyu Wang, Yingmin Zhang, Zhengtao Wang, Linnan Li*, and Li Yang*
    TrAC Trends in Analytical Chemistry, 2026
  8. J. Pharm. Anal.
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    Unraveling pyrrolizidine alkaloid-induced liver damage with an integrative spatial lipidomics framework
    Yilin Chen, Jie Xu, Thomas Ka-Yam Lam, Yanqiao Xie, Jianing Wang, Aizhen Xiong, Zhengtao Wang, Zongwei Cai, Linnan Li*, and Li Yang*
    Journal of Pharmaceutical Analysis, 2026

2025

  1. J. Pharm. Biomed. Anal.
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    LC-MS-based 3M profiling strategy and network pharmacology reveal ginsenoside diversity and bioactivity transformation during decoction of the Shengmai formula
    Longchan Liu, Haoyue Zhang, Linnan Li, Wenxiang Fan*, Li Yang*, and Zhengtao Wang*
    Journal of Pharmaceutical and Biomedical Analysis, 2025
  2. Microchim. Acta
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    Development of three-dimensional boronate affinity dendritic mesoporous silica coupled with HPLC-CAD for selective determination of ginsenosides
    Weiman Zhao, Wenxiang Fan, Longchan Liu, Yingrui Gao, Ruonan Tong, Liying You, Linnan Li*, Zhengtao Wang*, and Li Yang*
    Microchimica Acta, 2025
  3. JPC
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    Identification of antibacterial compounds in various Perillae folium chemotypes by high-performance thin-layer chromatography-bioassay-mass spectrometry
    Zihao Si, Mooseob Kim, Lihua Gu*, Linnan Li, Li Yang, and Zhengtao Wang*
    JPC–Journal of Planar Chromatography–Modern TLC, 2025
  4. J. Pharm. Biomed. Anal.
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    A complementary and integrated strategy for multicomponent characterization and attribution of Danning tablet based on convergence and liquid chromatography combined with mass spectrometry
    Yu Wang, Zhengcai Ju, Linnan Li, Siyu Zhang, Zhengtao Wang*, and Li Yang*
    Journal of Pharmaceutical and Biomedical Analysis, 2025
  5. Analyst
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    Rapid on-site identification of pyrrolizidine alkaloids in herbal medicines using miniature mass spectrometry
    Xiyue Yang, Xingyu Wang, Yilin Chen, Ziying Wang, Dan Zhang, Nan Wang, Zhengtao Wang, Aizhen Xiong*, Linnan Li*, and Li Yang*
    Analyst, 2025
  6. J. Anal. Test.
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    On-site analysis and rapid authentication of valuable agarwood samples by paper capillary spray miniature mass spectrometry
    Yanqiao Xie, Shengqi Huang, Qian Zhang, Siyu Zhang, Zhuzhen Han, Jinliang Yu, Xingyu Wang, Kaixian Chen*, Zhengtao Wang, Linnan Li*, and Li Yang*
    Journal of Analysis and Testing, 2025
  7. Chin. J. Nat. Med.
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    Metabolomics as an emerging tool for the pharmacological and toxicological studies on Aconitum alkaloids
    Han Ding, Yamin Liu, Sifan Wang, Yuqi Mei, Linnan Li*, Aizhen Xiong, Zhengtao Wang, and Li Yang*
    Chinese Journal of Natural Medicines, 2025
  8. Talanta
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    An integrated 3-M workflow for accelerated annotation of natural products: Flavonoids in Daemonorops draco as a case study
    Wenxiang Fan, Ziwei Li, Longchan Liu, Yu Wang, Kaixian Chen, Linnan Li, Zhengtao Wang*, and Li Yang*
    Talanta, 2025
  9. J. Pharm. Biomed. Anal.
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    Enhanced bile acid detection and analysis in liver fibrosis with pseudo-targeted metabolomics
    Zhizhi Hu, Jiaojiao Wei, Kua Dong, Linnan Li, Aizhen Xiong, Li Yang, and Zhengtao Wang
    Journal of Pharmaceutical and Biomedical Analysis, 2025
  10. J. Pharm. Biomed. Anal.
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    Targeted metabolomics for multiple energy metabolites of tricarboxylic acid cycle, glycolysis and oxidative phosphorylation pathway in MAFLD: From analytical method development towards application to authentic samples in mice and human
    Kangning Fu, Xing Yan, Lizhu Chen, Hechen Wang, Qiong Lai, Linnan Li, Zhengtao Wang, Rui Wang*, Lili Ding*, and Li Yang*
    Journal of Pharmaceutical and Biomedical Analysis, 2025
  11. J. Pharm. Biomed. Anal.
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    Rapid identification and on-site analysis of phytochemical markers for fragrant rosewood based on miniature mass spectrometry
    Siyu Zhang, Linnan Li, Yanqiao Xie, Linhong Fan, Yu Wang, Nan Wang, Zhuzhen Han, Zhengtao Wang, Kaixian Chen*, and Li Yang*
    Journal of Pharmaceutical and Biomedical Analysis, 2025

2024

  1. Rapid Commun. Mass Spectrom.
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    On-site analysis and rapid identification of citrus herbs by miniature mass spectrometry and machine learning
    Xingyu Wang, Yanqiao Xie, Jinliang Yu, Ye Chen, Yun Tian, Ziying Wang, Zhengtao Wang, Linnan Li*, and Li Yang*
    Rapid Communications in Mass Spectrometry, 2024
  2. Analyst
    wang2024analyst.jpg
    Rapid analysis of bioactive compounds from citrus samples by direct analysis in real-time mass spectrometry combined with chemometrics
    Xingyu Wang, Yilin Chen, Yanqiao Xie, Yamin Liu, Linhong Fan, Linnan Li*, Zhengtao Wang, and Li Yang*
    Analyst, 2024
  3. Chem. Commun.
    xie2024chemcomm.jpg
    Uncovering the secrets of agarwood aroma with regions and grades using a comprehensive analytical strategy
    Yanqiao Xie, Chen Shen, Ge Yin, Siyu Zhang, Yilin Chen, Wenxiang Fan, Kaixian Chen, Zhengtao Wang, Linnan Li*, and Li Yang*
    Chemical Communications, 2024
  4. J. Chromatogr. A
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    Comprehensive profiling of amino acids and derivatives in biological samples: a robust UHPLC-MS/MS method for investigating acute lung injury
    Yamin Liu, Xunjiang Wang, Jiaojiao Wei, Kangning Fu, Yilin Chen, Linnan Li*, Zhengtao Wang*, and Li Yang*
    Journal of Chromatography A, 2024
  5. Phytomedicine
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    Pharmacological mechanisms of traditional Chinese medicine against acute lung injury: from active ingredients to herbal formulae
    Yamin Liu, Xunjiang Wang, Yilin Chen, Limei Zhou, Yining Wang, Linnan Li*, Zhengtao Wang*, and Li Yang*
    Phytomedicine, 2024
  6. Food Chem.
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    Mass spectrometric analysis strategies for pyrrolizidine alkaloids
    Yilin Chen, Linnan Li*, Jie Xu, Yamin Liu, Yanqiao Xie, Aizhen Xiong, Zhengtao Wang, and Li Yang*
    Food Chemistry, 2024
  7. Phytochem. Rev.
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    Mass spectrometry imaging: an emerging technology in plant molecular physiology
    Wenxu Lu, Junhao Wang, Yanqiao Xie, Sijia Wu, Linnan Li*, and Hong Xu*
    Phytochemistry Reviews, 2024
  8. Phytomedicine
    liu2024phytomed2.jpg
    A versatile "Monomethod-Multiuse" strategy based on HPLC-CAD for quality control of Shengmai Formula from raw materials to preparations
    Longchan Liu, Wenxiang Fan, Haoyue Zhang, Linhong Fan, Yuqi Mei, Ziying Wang, Linnan Li, Li Yang*, and Zhengtao Wang*
    Phytomedicine, 2024
  9. J. Adv. Res.
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    Rare ginsenosides: a unique perspective of ginseng research
    Wenxiang Fan, Linhong Fan, Ziying Wang, Yuqi Mei, Longchan Liu, Linnan Li, Li Yang*, and Zhengtao Wang*
    Journal of Advanced Research, 2024
  10. J. Ethnopharmacol.
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    An innovative processing driven efficient transformation of rare ginsenosides enhances anti-platelet aggregation potency of notoginseng by integrated analyses of processing-(chemical) profiling-pharmacodynamics
    Wenxiang Fan, Qi Liao, Linhong Fan, Qi Li, Longchan Liu, Ziying Wang, Yuqi Mei, Linnan Li, Li Yang*, and Zhengtao Wang*
    Journal of Ethnopharmacology, 2024

2023

  1. Front. Chem.
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    Editorial: New strategies for analysis and evaluation of pharmaceuticals and natural products
    Linnan Li
    Frontiers in Chemistry, 2023
  2. Anal. Chem.
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    Ion mobility mass spectrometry for the separation and characterization of small molecules
    Longchan Liu, Ziying Wang, Qian Zhang, Yuqi Mei, Linnan Li*, Huwei Liu, Zhengtao Wang, and Li Yang*
    Analytical Chemistry, 2023
  3. J. Pharm. Anal.
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    Targeted bile acids metabolomics in cholesterol gallbladder polyps and gallstones: from analytical method development towards application to clinical samples
    Jiaojiao Wei#, Tao Chen#, Yamin Liu#, Shuai Sun, Zhiqing Yuan, Yixin Zhang, Aizhen Xiong, Linnan Li*, Zhengtao Wang*, and Li Yang*
    Journal of Pharmaceutical Analysis, 2023
  4. ACS Sustain. Chem. Eng.
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    Sustainable mechanochemical-assisted extraction of active saponins from plants with solid acid and alkalis
    Linhong Fan, Wenxiang Fan, Qian Zhang, Longchan Liu, Ziying Wang, Yuqi Mei, Linnan Li, Zhengtao Wang*, and Li Yang*
    ACS Sustainable Chemistry & Engineering, 2023
  5. Rapid Commun. Mass Spectrom.
    liu2023rcm.jpg
    A comprehensive profiling of renin–angiotensin system in mouse and human plasma by a rapid quantitative analysis of 14 angiotensin peptides using ultrahigh-performance liquid chromatography with tandem mass spectrometry
    Yamin Liu, Linnan Li, Zhengtao Wang*, and Li Yang*
    Rapid Communications in Mass Spectrometry, 2023
  6. J. Pharm. Biomed. Anal.
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    Study on herb-herb interaction between active components of Plantago asiatica L. seed and Coptis chinensis Franch. rhizoma based on transporters using UHPLC-MS/MS
    Jieyu Zhang, Yan Chen, Wenxiang Fan, Linnan Li, Yueming Ma, Zhengtao Wang, Rong Shi*, and Li Yang*
    Journal of Pharmaceutical and Biomedical Analysis, 2023
  7. Phytomedicine
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    Red ginseng extracts ameliorate high-fat diet-induced obesity and insulin resistance by activating the intestinal TGR5-mediated bile acids signaling pathway
    Wei Li#, Tongxi Zhuang#, Zixuan Wang, Xunjiang Wang, Longchan Liu, Yixuan Luo, Rufeng Wang, Linnan Li, Wendong Huang, Zhengtao Wang*, Li Yang*, and Lili Ding*
    Phytomedicine, 2023
  8. Mass Spectrom. Rev.
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    Advances in mass spectrometry imaging for toxicological analysis and safety evaluation of pharmaceuticals
    Yilin Chen#, Yanqiao Xie#, Linnan Li*, Zhengtao Wang, and Li Yang*
    Mass Spectrometry Reviews, 2023

2022

  1. Analyst
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    Rapid analysis of differential chemical compositions of Poria cocos using thin-layer chromatography spray ionization-mass spectrometry
    Ying Yang, Linnan Li*, Na Li, Fan Li, Wenxiang Fan, Yitian He, Zhengtao Wang*, and Li Yang*
    Analyst, 2022
  2. Molecules
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    Development of green and efficient extraction of bioactive ginsenosides from Panax ginseng with deep eutectic solvents
    Yujia Tu, Linnan Li*, Wenxiang Fan, Longchan Liu, Zhengtao Wang, and Li Yang*
    Molecules, 2022
  3. J. Ethnopharmacol.
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    The history, stereochemistry, ethnopharmacology and quality assessment of borneol
    Yuqi Mei, Linnan Li, Linghong Fan, Wenxiang Fan, Longchan Liu, Fangli Zhang, Zhizhi Hu, Kang Wang, Li Yang, and Zhengtao Wang*
    Journal of Ethnopharmacology, 2022
  4. J. Chromatogr. A
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    A complementary chromatographic strategy for integrated components characterization of Imperatae Rhizoma based on convergence and liquid chromatography combined with mass spectrometry and molecular network
    Yu Wang, Zhengcai Ju, Linnan Li, Ting Zhang, Siyu Zhang, Lili Ding, Changsen Zhan, Zhengtao Wang, and Li Yang*
    Journal of Chromatography A, 2022
  5. Trends Food Sci. Technol.
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    Mechanochemical assisted extraction as a green approach in preparation of bioactive components extraction from natural products - A review
    Linhong Fan, Wenxiang Fan, Yuqi Mei, Longchan Liu, Linnan Li, Zhengtao Wang*, and Li Yang*
    Trends in Food Science & Technology, 2022
  6. Phytomedicine
    fan2022phytomed.jpg
    Mass spectrometry-based profiling and imaging strategy, a fit-for-purpose tool for unveiling the transformations of ginsenosides in Panax notoginseng during processing
    Wenxiang Fan, Yuangui Yang, Linnan Li, Linhong Fan, Zhengtao Wang*, and Li Yang*
    Phytomedicine, 2022
  7. Rapid Commun. Mass Spectrom.
    zhang2022rcm.jpg
    Rapid identification of bear bile powder from other bile sources using chip-based nano-electrospray ionization tandem mass spectrometry
    Yixin Zhang, Jiaojiao Wei, Linnan Li, Yamin Liu, Shuai Sun, Lu Xu, Shaoyong Liu, Zhengtao Wang, and Li Yang*
    Rapid Communications in Mass Spectrometry, 2022
  8. J. Pharm. Biomed. Anal.
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    Targeted metabolomics profiles serum fatty acids by HFD induced non-alcoholic fatty liver in mice based on GC-MS
    Xing Yan, Linnan Li, Pei Liu, Jie Xu, Zhengtao Wang, Lili Ding*, and Li Yang*
    Journal of Pharmaceutical and Biomedical Analysis, 2022
  9. JPC
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    Stimulation quantification of four natural lipase inhibitors from Alismatis Rhizoma by high-performance thin-layer chromatography method
    Fei Yang, Mooseob Kim, Lihua Gu*, Linnan Li, Li Yang, and Zhengtao Wang*
    JPC–Journal of Planar Chromatography–Modern TLC, 2022

2021

  1. J. Chromatogr. A
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    Characterization of natural herbal medicines by thin-layer chromatography combined with laser ablation-assisted direct analysis in real-time mass spectrometry
    Yilin Chen, Linnan Li*, Rui Xu, Fan Li, Lihua Gu, Huwei Liu, Zhengtao Wang, and Li Yang*
    Journal of Chromatography A, 2021
  2. Food Chem.
    chen2021foodchem.jpg
    Rapid identification and determination of pyrrolizidine alkaloids in herbal and food samples via direct analysis in real-time mass spectrometry
    Yilin Chen, Linnan Li*, Fen Xiong, Yanqiao Xie, Aizhen Xiong, Zhengtao Wang, and Li Yang*
    Food Chemistry, 2021
  3. J. Sep. Sci.
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    Development and applications of deep eutectic solvents derived functional materials in chromatographic separation
    Linnan Li#, Yamin Liu#, Zhengtao Wang, Li Yang*, and Huwei Liu*
    Journal of Separation Science, 2021
    Wiley Top Cited Article 2021-2022
  4. J. Pharm. Biomed. Anal.
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    Advances in analytical techniques and quality control of traditional Chinese medicine injections
    Yujia Tu, Linnan Li, Zhengtao Wang, and Li Yang*
    Journal of Pharmaceutical and Biomedical Analysis, 2021

2020

  1. Coord. Chem. Rev.
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    Recent advances in applications of metal–organic frameworks for sample preparation in pharmaceutical analysis
    Linnan Li, Yilin Chen, Li Yang, Zhengtao Wang*, and Huwei Liu*
    Coordination Chemistry Reviews, 2020
  2. Anal. Bioanal. Chem.
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    Rapid and sensitive analysis of progesterone by solid-phase extraction with amino-functionalized metal-organic frameworks coupled to direct analysis in real-time mass spectrometry
    Linnan Li, Yilin Chen, Yuangui Yang, Ying Yang, Li Yang*, and Zhengtao Wang*
    Analytical and Bioanalytical Chemistry, 2020
  3. Anal. Bioanal. Chem.
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    Fully automated chip-based nanoelectrospray ionization-mass spectrometry as an effective tool for rapid and high-throughput screening of 5α-reductase inhibitors
    Ruirong Zheng, Linnan Li, Xueli Deng, Mei Tian, Zhengtao Wang*, and Li Yang*
    Analytical and Bioanalytical Chemistry, 2020
  4. Phytochem. Anal.
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    Rapid authentication of the agarwood by using liquid extraction surface analysis-mass spectrometry (LESA-MS)
    Yanqiao Xie, Linnan Li, Yilin Chen, Yuangui Yang, Hong Xu*, Zhengtao Wang, and Li Yang*
    Phytochemical Analysis, 2020
  5. Chin. J. Nat. Med.
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    Advances on hormone-like activity of Panax ginseng and ginsenosides
    Mei Tian, Linnan Li, Ruirong Zheng, Li Yang, and Zhengtao Wang*
    Chinese Journal of Natural Medicines, 2020

2019

  1. Anal. Bioanal. Chem.
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    Facile one-step solvothermal synthesis of a luminescent europium metal-organic framework for rapid and selective sensing of uranyl ions
    Linnan Li, Sensen Shen, Jie Su, Wanpeng Ai, Yu Bai, and Huwei Liu*
    Analytical and Bioanalytical Chemistry, 2019

2018

  1. Sens. Actuators B
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    Facilely synthesized Eu3+ post-functionalized UiO-66-type metal-organic framework for rapid and highly selective detection of Fe3+ in aqueous solution
    Linnan Li, Sensen Shen, Wanpeng Ai, Shiyao Song, Yu Bai*, and Huwei Liu*
    Sensors and Actuators B: Chemical, 2018
  2. Nanoscale
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    Metal-organic frameworks induce autophagy in mouse embryonic fibroblast cells
    Sensen Shen, Linnan Li, Songyue Li, Yu Bai*, and Huwei Liu
    Nanoscale, 2018
  3. Int. J. Mass Spectrom.
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    Metabolomic study of mouse embryonic fibroblast cells in response to autophagy based on high resolution gas chromatography-mass spectrometry
    Sensen Shen, Linnan Li, Shiyao Song, Yu Bai*, and Huwei Liu
    International Journal of Mass Spectrometry, 2018
  4. Anal. Chim. Acta
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    Lipid metabolism in mouse embryonic fibroblast cells in response to autophagy induced by nutrient stress
    Sensen Shen, Li Yang, Linnan Li, Yu Bai*, and Huwei Liu
    Analytica Chimica Acta, 2018

2017

  1. Chem. Commun.
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    Rapid and specific luminescence sensing of Cu(II) ion with porphyrinic metal-organic framework
    Linnan Li, Sensen Shen, Ruoyun Lin, Yu Bai, and Huwei Liu*
    Chemical Communications, 2017
  2. J. Chromatogr. B
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    A plasma lipidomics strategy reveals perturbed lipid metabolic pathways and potential lipid biomarkers of human colorectal cancer
    Sensen Shen, Li Yang, Linnan Li, Chun Cai, Yu Bai, and Huwei Liu*
    Journal of Chromatography B, 2017
  3. Anal. Bioanal. Chem.
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    Lipidomic analysis of plasma in patients with lacunar infarction using normal-phase/reversed-phase two-dimensional liquid chromatography-quadrupole time-of-flight mass spectrometry
    Li Yang, Pu Lv, Wanpeng Ai, Linnan Li, Sensen Shen, Honggang Nie, Yabing Shan, Yu Bai, Yining Huang*, and Huwei Liu*
    Analytical and Bioanalytical Chemistry, 2017

2016

  1. ACS Appl. Mater. Interfaces
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    A combined experimental and theoretical study on the extraction of uranium by amino-derived metal–organic frameworks through post-synthetic strategy
    Linnan Li, Wen Ma, Sensen Shen, Hexiang Huang, Yu Bai, and Huwei Liu*
    ACS Applied Materials & Interfaces, 2016
  2. Electrophoresis
    li2016electrophoresis.jpg
    Study on the interaction of uranyl with sulfated beta-cyclodextrin by affinity capillary electrophoresis and molecular dynamics simulation
    Linnan Li, Yiding Zhang, Xianjiang Li, Sensen Shen, Hexiang Huang, Yu Bai, and Huwei Liu*
    Electrophoresis, 2016
  3. Sci. Rep.
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    Metabolomic analysis of mouse embryonic fibroblast cells in response to autophagy induced by acute starvation
    Sensen Shen, Rui Weng, Linnan Li, Xinyuan Xu, Yu Bai*, and Huwei Liu
    Scientific Reports, 2016

2015

  1. Electrophoresis
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    Binding constant determination of uranyl-citrate complex by ACE using a multi-injection method
    Yiding Zhang, Linnan Li, Hexiang Huang, Linnan Xu, Ze Li, Yu Bai, and Huwei Liu*
    Electrophoresis, 2015
  2. Mass Spectrom. Lett.
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    Direct analysis in real time mass spectrometry: a powerful tool for fast analysis
    Xianjiang Li, Xin Wang, Linnan Li, Yu Bai, and Huwei Liu*
    Mass Spectrometry Letters, 2015